MONITORING DYNAMIC CHANGES OF CELLULAR MEMBRANE GSH DURING STROKE VIA AN ESIPT-BASED NEAR-INFRARED FLUORESCENT PROBE

Monitoring Dynamic Changes of Cellular Membrane GSH During Stroke via an ESIPT-Based Near-Infrared Fluorescent Probe

Stroke, primarily ischemic (85%), results from inadequate blood supply and is worsened by ferroptosis, characterized by free radical generation and lipid peroxidation.Monitoring ferroptosis is essential for understanding its mechanisms and developing treatments.Glutathione (GSH) is a key ferroptosis biomarker, ACNEDOTE WASH but current probes are l

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Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Weitao Fu,1,* Lingfeng Chen,1,* Zhe Wang,1 Chengwei Zhao,1 Gaozhi Chen,1 Xing Liu,1 Yuanrong Dai,2 Yuepiao Cai,1 Chenglong Li,1,3 Jianmin Zhou,1 Guang Liang1 1Chemical Biology Research Center, School of Pharmaceutical Sciences, 2Department of Respiratory Medicine, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People

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